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The Precautionary and Prohibited Medications Database

Maintained by a collaboration of the University at Buffalo Pharmacology Specialty Laboratory and Frontier Science & Technology Research Foundation

The precautionary and prohibited medications database is a utility for investigators to use during protocol development and implementation

About the database

The Precautionary and Prohibited Medications Database was created to assist AIDS Clinical Trials Group (ACTG) investigators and research staff during protocol development and the conduct of clinical studies. Investigators and research staff may access the most current pharmacokinetic data regarding drug-drug interactions for medications utilized in each of several ACTG scientific focus areas. More information on ACTG research focus areas can be found at the following web address: https://actgnetwork.org/committees/scientific

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Data Sources

The data in the database comes from a variety of sources, such as research conferences and publications. Learn More

Recent Interactions

First Medication Second Medication Designation
Darunavir/Cobicistat Rifapentine/Isoniazid Prohibited View
Glecaprevir/Pibrentasvir Atazanavir Prohibited View
Glecaprevir/Pibrentasvir Efavirenz Prohibited View
Glecaprevir/Pibrentasvir Darunavir/Ritonavir Prohibited View

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Number of Drugs

Number of Drugs 359
Number of Interactions 905

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