The Precautionary and Prohibited Medications Database

A database for investigators during protocol development and implementation

What's in the Database

Medications 361
Interactions 908

COVID-19 Resources

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Recent Medications


ARV • 1 interactions


ARV • 1 interactions

Estradiol Valerate and spironolactone

Other • 1 interactions

Recent Interactions


HS-10234 vs Emtricitabine

Unknown or no reaction

Emtricitabine/Tenofovir Disoproxil Fumarate vs Estradiol Valerate and spironolactone

Unknown or no reaction

GSK3640254 vs Ethinylestradiol/Levonorgestrel

About the Database

The Precautionary and Prohibited Medications Database was created to assist AIDS Clinical Trials Group (ACTG) investigators and research staff during protocol development and the conduct of clinical studies. Investigators and research staff may access the most current pharmacokinetic data regarding drug-drug interactions for medications utilized in each of several ACTG scientific focus areas.

PPMD is a collaboration between ACTG, the University at Buffalo, and Frontier Science Foundation.


The data in the database comes from a variety of sources, such as research conferences and publications

Our review process:

  1. Scientific Contributors review research from the various sources listed below
  2. Relevant information is added into the database for review
  3. The database manager reviews the information for content and quality and adds them to the database


About the purpose and goals of PPMD

How It's Used

Examples of how PPMD data is being used

Data Sources

Overview of where our data comes from and how we analyze it


About the people and organizations behind PPMD